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Microfluidic droplet handling by bulk acoustic wave (BAW) acoustophoresis

机译:体声波(BAW)声泳处理微流体液滴

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Droplet microfluidics has emerged as a prospering field for lab-on-a-chip devices, where droplets serve as liquid vessels e.g. for biochemical reagents. Key to the fluid processing in droplet format are the controlled droplet handling and movement on the microscale. Hence this paper proposes droplet handling by combining droplet microfluidics with bulk acoustic wave (BAW) acoustophoresis. BAW acoustophoresis has formerly focused on cell and particle handling, whereas here we determine the various abilities of this method for the field of droplet microfluidics. In silicon microdevices, water-in-oil droplets of 200 mu m size were generated for a set of unit operations including droplet fusion, focusing, sorting and medium exchange around 0.5-1 MHz acoustic frequency. Compared to existing droplet handling methods, the shown method is simple in fabrication, robust in operation and versatile to meet the needs of various droplet processing microfluidic devices.
机译:液滴微流体已经成为芯片实验室设备的繁荣领域,其中液滴充当液体容器,例如液体容器。用于生化试剂。以液滴形式进行流体处理的关键是在微尺度上受控的液滴处理和移动。因此,本文提出了将液滴微流控技术与体声波(BAW)声泳相结合的液滴处理方法。 BAW声学电泳以前主要关注细胞和颗粒的处理,而在此我们确定了该方法在液滴微流体领域的各种功能。在硅微器件中,产生了200微米大小的油包水液滴,用于一系列单元操作,包括液滴融合,聚焦,分选和0.5-1 MHz声频附近的介质交换。与现有的液滴处理方法相比,所示的方法制造简单,操作鲁棒并且通用,以满足各种液滴处理微流体装置的需求。

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