Integrated microreaction system for optical resolution of racemic amino acids

摘要

We developed a novel microreaction system for optical resolution of racemic amino acids.This device,which is based on a continuous microfluidic system,consists of an enzyme-immobilized microreactor and a microextractor.Use of the enzyme-microreactor,which was prepared by membrane formation on the microchannel surface,enabled a highly enantioselective reaction for a racemic amino acid derivative.The microextractor provided a laminar flow of two immiscible solutions,which enabled selective extraction of the product.Using this integrated device,we could perform efficient continuous production of optically pure unnatural amino acids.