Improving Cell Culture Process

摘要

While small molecules arc produced using comparatively siui|ilr chemical processes, biologies are developed using genetically engineered microorganisms, which means thai production processes must continuously monitor the health and development of these organisms. In addition to increased process complexity, the biologic drugs themselves present characterization challenges, also known as "large molecule" drugs, biologies are large proteins with masses as high as 150,000 Daltons, which is more than 150 limes the upper mass limit of small molecule pharmaceuticals.