Time to stop horsing around?

摘要

Fndotoxins are lipopolysaccharide complexes associated with the outer membrane of Gram-negative bacteria, which can elicit a number of undesirable pyrogenic effects in humans and animals, including septic shock, fever, vascular collapse and even death. Pharmaceuticals such as vaccines, implantable medical devices, and intravenous drugs and fluids can become contaminated with endotoxins leading to serious consequences. It is therefore of paramount importance that thorough screening of medical products and pharmaceuticals is conducted prior to patient administration. Endotoxins can also contaminate in vitro cell cultures, such as those used in research and bioproduction, impacting cell growth and function. For this reason, it is also vital that researchers safeguard against endotoxin contamination.