Olefin cross-metathesis in natural product synthesis: preparation of trisubstituted olefins on the way to vitamin E

摘要

The application of ruthenium catalyzed olefin cross-metathesis towards the synthesis of tocopherols(vitamin E) is described.This group of biologically most important fat-soluble antioxidants is synthetically available by various routes,for which key-intermediates containing trialkyl-substituted olefinic double bonds can now be prepared efficiently.The results presented may be of interest for the area of syntheses of isoprenoid natural products in general.