Anticoagulant therapy in acute brain ischaemia.

摘要

Thrombosis plays an important part in acute ischaemic stroke, and antithrombotic therapies are a logical approach to treatment. Heparin has been advocated for acute stroke since the 1950s,1 and by the 1980s, patients with acute ischaemic stroke and transient ischaemic attack were routinely treated with intravenous heparin with the aim of reducing progression of ischaemia and preventing early stroke recurrence. Since then, multiple randomised trials have tested heparins (unfractionated heparin, low-molecular-weight heparin, and heparinoids) and other anticoagulants in acute stroke.