New lexicon and criteria for the diagnosis of Alzheimer's disease.

摘要

We have been following the proposed diagnostic criteria for Alzheimer's disease (AD) closely over the past few years. Recent revisions of the AD criteria proposed by Dubois and colleagues represent a clear improvement on their previously published Position Paper. In the new revision, Dubois and colleagues propose an important distinction between the clinical disorder (AD) and the neuropathological condition ("Alzheimer's pathology"). They also describe several distinctions within the clinical disorder, including two preclinical conditions ("asymptomatic at-risk for AD" and "presymptomatic AD"), a prodromal condition ("prodromal AD"), and AD dementia with varying presentations ("typical AD," "atypical AD", and "mixed AD"). The authors provide an evidence-based structure to improve the clarity of predementia conditions, particularly for individuals previously diagnosed with mild cognitive impairment but with biomarker evidence of AD pathology, who are now classified as having prodromal AD