Renal disorders associated with monoclonal §ammopa-thies; Diagnostic and therapeutic progress

摘要

Various renal disorders are associated with monoclonal gommopatbies, secondary to tissue deposition or precipitation of a monoclonal immunoglohulin (ig) or a fragment thereof (isolated Ig light chain or heavy chain). They are classified according to the localization of renal lesions, either glomerular or tubular and to the pattern of ultrastructural organization of Ig deposits. Renal disease in monoclonal gammopathies may be isolated, or associated with various systemic symptoms particularly in AL amyloidosis, Randall-type monoclonal Ig deposition disease and monoclonal cryo-globulinemias.