NUMERICAL METHODS FOR ESTIMATING EFFECTIVE DIFFUSION COEFFICIENTS OF THREE-DIMENSIONAL DRUG DELIVERY SYSTEMS

摘要

This paper presents a numerical technique in three dimensions for estimating effective diffusion coefficients of drug release devices in rotating and flow-through fluid systems. We first formulate the drug release problems as diffusion equation systems with unknown effective diffusion coefficients. We then develop a numerical technique for estimating the unknown coefficients based on a nonlinear least-squares method and a finite volume discretization scheme for the 3D diffusion equations. Numerical experiments have been performed using experimental data and the numerical results are presented to show that our methods give accurate diffusivity estimations for the test problems.