Palliative care of bone pain due to skeletal metastases: Exploring newer avenues using neutron activated Ca-45

摘要

Introduction: With an objective to develop a cost-effective radiochemical formulation for palliation of pain due to skeletal metastases, we have demonstrated a viable method for large-scale production of Ca-45 (t(1/2) = 163 days, E-beta max = 03 MeV) using moderate flux research reactor, its purification from radionuclidic impurities adopting electrochemical approach and preclinical evaluation of (CaCl2)-Ca-45.