首页> 外文期刊>Nuclear Medicine and Biology >18F)-2-fluoro-2-deoxyglucose transport kinetics as a function of extracellular glucose concentration in malignant glioma, fibroblast and macrophage cells in vitro.
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18F)-2-fluoro-2-deoxyglucose transport kinetics as a function of extracellular glucose concentration in malignant glioma, fibroblast and macrophage cells in vitro.

机译:18F)-2-氟-2-脱氧葡萄糖的运输动力学与体外恶性神经胶质瘤,成纤维细胞和巨噬细胞中细胞外葡萄糖浓度的关系。

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摘要

FDG-PET is used to measure the metabolic rate of glucose. Transport and phosphorylation determine the amount of hexose analog that is phosphorylated and trapped. Competition occurs for both events, such that extracellular glucose concentration affects the FDG image. This study investigated the effect of glucose concentration on the rate of FDG accumulation in three cell lines. The results show that extracellular glucose concentration has a greater impact on the rate of FDG accumulation than the relative abundance of GLUT transporter subtypes.
机译:FDG-PET用于测量葡萄糖的代谢率。运输和磷酸化确定磷酸化和捕获的己糖类似物的量。两种事件都发生竞争,从而使细胞外葡萄糖浓度影响FDG图像。这项研究调查了葡萄糖浓度对三种细胞系中FDG积累速率的影响。结果表明,细胞外葡萄糖浓度对FDG积累速率的影响大于GLUT转运蛋白亚型的相对丰度。

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