首页> 外文期刊>Nuclear Medicine and Biology >The PEGylated liposomal doxorubicin improves the delivery and therapeutic efficiency of Re-188-Liposome by modulating phagocytosis in C26 murine colon carcinoma tumor model
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The PEGylated liposomal doxorubicin improves the delivery and therapeutic efficiency of Re-188-Liposome by modulating phagocytosis in C26 murine colon carcinoma tumor model

机译:聚乙二醇化脂质体阿霉素通过调节C26鼠结肠癌肿瘤模型中的吞噬作用来改善Re-188-脂质体的递送和治疗效率

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摘要

Liposome in delivering radionuclide for cancer therapy has been expansively studied; however, liposome itself can be deliberately entrapped and destroyed by the reticuloendothelial system, causing an insufficiency of the drug delivery, which in turn would restrict the effectiveness of the drug. In this study, mice with subcutaneous implantation of C26 murine colon cancer received an experimental treatment regimen in which mice took delivery of PEGylated liposomal doxorubicin (LipoDox) first, after a three-day interval, of Rhenium-188 encapsulated into PEGylated liposome (Re-188-Liposome) subsequently and by which suppressed the functioning of reticuloendothelial system for the short term. The data showed that based upon the biodistribution assay and the evaluation of the therapeutic efficacy, Re-188-Liposome was more sufficiently delivered to tumor sites in mice with this treatment regimen than mice without the regimen, and that cancer mortalities in mice with the treatment regimen were much lower than the mortalities in mice without the regimen. Taken together, a new strategy proposed in this study significantly improved both the Re-188-Liposome delivery and the effectiveness of Re-188-Liposome, suggesting that the strategy can be an ideal treatment for cancer. (C) 2014 Elsevier Inc. All rights reserved.
机译:已经广泛研究了脂质体递送放射性核素用于癌症治疗的研究。然而,脂质体本身可能被网状内皮系统故意截留并破坏,从而导致药物输送不足,进而限制了药物的有效性。在这项研究中,皮下植入C26鼠结肠癌的小鼠接受了一种实验性治疗方案,其中小鼠在三天的间隔后首先服用PEG化脂质体阿霉素(LipoDox),将Rhenium-188封装在PEG化脂质体中(Re- 188-脂质体)随后抑制了网状内皮系统的功能。数据显示,基于生物分布测定法和治疗效果的评估,与未使用该方案的小鼠相比,使用该治疗方案的小鼠将Re-188-脂质体更充分地递送至肿瘤部位,并且接受该治疗的小鼠中的癌症死亡率该方案比没有方案的小鼠的死亡率要低得多。综上所述,这项研究中提出的新策略显着改善了Re-188-脂质体的递送和Re-188-脂质体的有效性,表明该策略可以是治疗癌症的理想方法。 (C)2014 Elsevier Inc.保留所有权利。

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