THE EFFECT OF ANTIBODIES AGAINST CELL-SURFACE ADHESION MOLECULES (LFA-1-ALPHA AND ICAM-1) ON THE MIGRATION AND LOCALIZATION OF TC-99M-LABELED LEUKOCYTES IN ACUTE INFECTION

摘要

The deficiency of adhesion molecules on leukocytes could severely impair their ability to migrate and perform effective immunological functions leading to clinical situations such as LAD (leukocyte adhesion deficiency) syndrome. We investigated the effects of blocking anti-LFA-1 alpha and ICAM-1 antibody-treated Tc-99m-labeled leukocytes on the migration and localization to the site of E. coli-induced acute infection in CBA/J mice. A significant inhibition of migration and localization of antibody-treated leukocytes to the site of infection was observed, reaffirming the vital role of these adhesion molecules, especially during scintigraphic examination of patients for deep infections or abscess using labeled leukocytes. [References: 13]