Imaging [F-18]FAU [1-(2 '-deoxy-2 '-fluoro-beta-D-arabinofuranosyl)uracil] in dogs

摘要

We have studied the biodistribution of [F-18]FAU [(1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil], which previous work has shown is incorporated into DNA and functions as an inhibitor of DNA synthesis. It is being tested as a potential antineoplastic agent and imaging agent for PET. We have produced [F-18]FAU and injected the tracer into 3 normal dogs and imaged them for up to 4 hours and removed tissues along with blood and urine samples for HPLC and activity analysis. The result, showed that [F-18]FAU evenly distributed to most of organs. In sharp contrast to our prior experience with thymidine and its analogs, marrow had less retention of [F-18]FAU than the non-proliferating tissues. (C) 2002 Elsevier Science Inc. All rights reserved. [References: 10]