首页> 外文期刊>Nucleosides, nucleotides and nucleic acids >Synthesis of modified nucleoside 5'-triphosphates for in vitro selection of catalytic nucleic acids.
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Synthesis of modified nucleoside 5'-triphosphates for in vitro selection of catalytic nucleic acids.

机译:合成修饰的5'-三磷酸核苷用于体外选择催化性核酸。

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摘要

2'-Modified pyrimidine nucleoside 5'-triphosphates comprising amino, imidazole and carboxylate functionality attached to the 5-position of the base were synthesized. Two different phosphorylation methods were used to optimize the yields of these highly modified triphosphates.
机译:合成了2'-修饰的嘧啶核苷5'-三磷酸酯,其包含连接到碱基5-位的氨基,咪唑和羧酸酯官能团。两种不同的磷酸化方法被用来优化这些高度改性的三磷酸酯的产率。

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