Antibiotic Susceptibility Pattern of ES ß L Producing Klebsiella pneumoniae Isolated from Urine Samples of Pregnant Women in Karnataka

摘要

Background: Klebsiella pneumoniae possess a new problem to health care professionals worldwide, which complicates and limits therapeutic options. It is one of the leading nosocomial bacterial pathogens, and the present study aims to determine the prevalence of ES ß L producing K. pneumoniae isolates with their antibiotic susceptibility pattern in urine samples of the pregnant women with UTI.Materials and Methods: Using standard isolation and identification procedures a total of 41 isolates were obtained from 417 midstream urine samples of pregnant women with suspected UTI in Karnataka. The antibiotic resistance profile of each isolate was performed by Kirby-Bauer disc diffusion method and ES ß L production by standard phenotypic method.Results: Isolation rate of K. pneumoniae in pregnant women was 19.9 and overall incidence rate was 9.8. Among the 41 K. pneumoniae isolates, 26 (63.4) were ES ß L producers and all were found to be Multi Drug Resistance (MDR). The antibiotic susceptibility test (AST) for the isolates revealed that the highest number of K. pneumoniae were resistant to ampicillin (75.6) followed by, nitrofurontoin and cefuroxime (73.1) and least to chloramphenicol (12.1). ES ß L producers were highly resistance to nitrofurontoin (69.2) and cotrimonazole (65.2) and lower resistance was (7.6) to amaikacin, observed. A higher resistance pattern to these two antibiotics was observed against ES ß L non producing K. pneumonia but lowest to polymyxin B (13.3) instead of amikacin (26.6). All the isolates were found to be susceptible to imipenem.Conclusion: Present investigation revealed high prevalence of MDR- ES ß L producing Klebsiella pneumoniae , which indicates dire need for effective ES ß L surveillance in the community by using cost effective antimicrobials agents.