Numerical Simulation of Hemodynamic and Physiological Responses of Human Cardiovascular and Respiratory System under Drugs Administration

摘要

The uptake of the drugs by human organisms has long been one of the primary concerns of pharmacological research. The numerical model of the human cardiovascular and respiratory system with the baroreflex and chemoreflex regulation including the physiologically-based pharmacokinetic model and also the model of the drug-cardiac cell channels interaction is developed at the IT CAS. The 24th segments model of pulsating type imitating the electrochemical and mechanical activity of heart muscle was used to the simulation of the antiarrhythmic drug (propranolol) effects on the themodynamic and physiologically behaviour of these systems.