Beneficial effects of grape resveratrol on serum adiponectin and inflammation: Clinical trial in patients with stable coronary artery disease

摘要

Coronary artery disease (CAD) is a leading cause of heart failure on a world-wide basis [1-3]. The epidemic proportion of CAD is increasing worldwide irrespective of gender [3, 4]. Coronary artery disease is associated with lower oxygen supply and demand ratio due to abnormalities of the coronary vasculature. The coronary arteries supply oxygenated blood to the heart muscle and due to the process of atherosclerosis leading to plaque rupture and acute coronary syndrome, myocardial blood supply is compromised leading to myocardial ischemia/infarction and heart failure [5, 6]. Many clinicians and cardiovascular researchers recognize the clinical as well as molecular pathophysiological basis of coronary artery disease. There are many research groups actively searching the intervention strategies to prevent CAD.