THE SYNAPTIC SPLIT OF SNAP-25: DIFFERENT ROLES IN GLUTAMATERGIC AND GABAERGIC NEURONS?

摘要

Normal brain function relies on the fine balance of activity between the two most widespread fast synapse populations in the CNS, the inhibitory GABAergic and the excitatory glutamatergic terminals. In the past years, evidence has accumulated demonstrating that GABAergic and glutamatergic neurons express different molecular components involved in neuronal development, intracellular signaling, and pre-postsynaptic functions. Among the molecules differentially distributed during development, the postsynaptic adhesion molecules neuroligin-1 and neuroli-gin-2 are localized at excitatory or inhibitory synapses (Varoqueaux et al., 2004, 2006), where they specifically increase excitatory and inhibitory synaptic responses, respectively (Chubykin et al., 2007)#