Evaluating the Status of Antiganglioside Antibodies in Children with Guillain-Barre Syndrome

摘要

Objective: Antiganglioside antibodies have been reported to play a role in the pathophysiology of Guillain-Barre syndrome (GBS). Methods: This case-control study was designed to evaluate the status of antiganglioside antibodies in children with GBS. The study included 50 patients suffering from GBS as the case group and 30 children as the control group. Clinical information such as demographic data and recent digestive or respiratory infection (within the last month) was collected for all patients, and paraclinical studies including cerebrospinal fluid examination and electrophysi-ology were conducted by a subspecialized physician. Anti-GM1, anti-GQ1 and anti-GDI a antibodies were measured with ELISA and the EUROLINE method. Results: The mean age of patients in the case and control groups was 5.3 ± 3.8 and 5.4 ± 3.4 years, respectively.