Efficient synthesis of lower rim alpha-hydrazino tetrazolocalix[4]arenes via an Ugi-azide multicomponent reaction

摘要

In this study, we developed an efficient synthesis of alpha-hydrazino tetrazolocalix[4] arene derivatives in good yields under mild conditions via an Ugi-azide multicomponent reaction. Metal ion binding properties of one of the alpha-hydrazino tetrazolocalix[4] arenes (7a) as the model compound were also investigated, revealing that compound 7a exhibits the highest binding affinity towards Ni(II).