Application of a thin film of poly(solochrome black T) as a redox mediator for the electro-catalytic simultaneous determination of dopamine and acetaminophen in the pharmaceutical and biological samples

摘要

Glassy carbon electrode was successfully modified with a thin film of poly(solochrome black T) and applied for the sensitive and selective voltammetric simultaneous determination of dopamine and acetaminophen. The preparation and basic electrochemical behavior of poly(solochrome black T) film on the glassy carbon electrode were investigated in details. The modified electrode with polymeric thin film exhibits excellent electro-catalytic activity toward the oxidation of dopamine and acetaminophen. The anodic peaks of the both species were well defined with lowered oxidation potential and enhanced oxidation peak currents. The modified electrode was used as a voltammetric sensor for sensitive simultaneous determination of dopamine and acetaminophen free from ascorbic acid and uric acid interferences. Under the optimum conditions, the detection limits were 0.092 and 0.142 mu mol L-1 for DA and AP, respectively. The proposed sensor has been successfully used in analysis of pharmaceutical and biological samples. (C) 2015 Elsevier B.V. All rights reserved.