A novel poly(gamma-glutamic acid)/silk-sericin hydrogel for wound dressing: Synthesis, characterization and biological evaluation

摘要

A novel multifunctional poly(gamma-glutamic acid)/silk sericin (gamma-PGA/SS) hydrogel has been developed and used as wound dressing. The physical and chemical properties of the gamma-PGA/SS gels were systemically investigated. Furthermore, these gamma-PGA/SS gels have been found to promote the L929 fibroblast cells proliferate, and in the in vivo study, significant stimulatory effects were also observed on granulation and capillary formation on day 9 in H-2-treated wounds, indicating that this new complex hydrogel could maintain a moist healing environment, protect the wound from bacterial infection, absorb excess exudates, and promote cell proliferation to reconstruct damaged tissue. Considering the simple preparation process and excellent biological property, this gamma-PGA/SS hydrogel might have a wide range of applications in biomedical and clinical areas. (C) 2014 Elsevier B.V. All rights reserved.