Folic acid-functionalized magnetic ZnFe_2O_4 hollow microsphere core/mesoporous silica shell composite particles: Synthesis and application in drug release

摘要

A drug delivery system was designed by deliberately combining the useful functions into one entity, which was composed of magnetic ZnFe_2O _4 hollow microsphere as the core, and mesoporous silica with folic acid molecules as the outer shell. Amine groups coated magnetic ZnFe _2O_4 hollow microsphere core/mesoporous silica shell (MZHM-MSS-NH_2) composite particles were first synthesized by a one-pot direct co-condensation method. Subsequently a novel kind of folic acid-functionalized magnetic ZnFe_2O_4 hollow microsphere core/mesoporous silica shell (MZHM-MSS-NHFA) composite particles were synthesized by conjugating folic acid as targeted molecule to MZHM-MSS-NH _2. Ibuprofen, a well-known antiphlogistic drug, was used as a model drug to assess the loading and releasing behavior of the composite microspheres. The results show that the MZHM-MSS-NHFA system has the higher capacity of drug storage and good sustained drug-release property.