首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >Neurotrophin-3 mRNA expression in rat intrafusal muscle fibres after denervation and reinnervation.
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Neurotrophin-3 mRNA expression in rat intrafusal muscle fibres after denervation and reinnervation.

机译:失神经支配和再神经支配后大鼠房内肌纤维中Neurotrophin-3 mRNA的表达。

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摘要

We have studied the regulation of the expression of neurotrophin-3 (NT-3) mRNA in neonatal and adult rat muscle spindles after denervation and after denervation followed by reinnervation. Denervation of the intrafusal fibres did not result in an upregulation of the NT-3 mRNA expression but decreased this expression below the detection limit of the in situ hybridization method. Reinnervation of intrafusal fibres restored the NT-3 mRNA expression. The results suggest that the expression of NT-3 mRNA in postnatal muscle spindles is controlled by neuronal factors. The intrafusal fibre derived NT-3 may act as an instructive, feedback messenger for innervating neurons and may play a role in stabilizing and maintaining functional neuromuscular connections.
机译:我们已经研究了神经营养蛋白3(NT-3)mRNA的表达在新生神经和成年大鼠肌肉纺锤神经支配后和神经支配后再神经支配。椎管内纤维的去神经化不会导致NT-3 mRNA表达的上调,但会将该表达降低到原位杂交方法的检测限以下。肌内纤维的神经支配恢复了NT-3 mRNA的表达。结果表明,NT-3 mRNA在产后肌梭中的表达受神经元因子控制。融合神经内纤维衍生的NT-3可以作为神经支配神经的指导性反馈信使,并且可以在稳定和维持功能性神经肌肉连接中发挥作用。

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