首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >The thymosin beta 4 gene is strongly activated in neural tissues during early postimplantation mouse development.
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The thymosin beta 4 gene is strongly activated in neural tissues during early postimplantation mouse development.

机译:在早期植入后小鼠发育过程中,胸腺素β4基因在神经组织中被强烈激活。

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摘要

We studied the temporal and spatial distribution of the mRNA encoding for thymosin beta 4 (T beta 4), a small acidic actin-sequestering peptide, during the early postimplantation mouse development. Analysis of total embryo RNA demonstrated a strong activation of T beta 4 gene after gastrulation and coincident with neurulation. In situ hybridization showed that T beta 4 mRNA was strongly expressed in the central nervous system and peripheral ganglia, paralleling the gradient of neuronal differentiation. An intense signal was also observed in intraventricular macrophages and blood vessels. The role of T beta 4 in mammalian neuroembryogenesis is discussed.
机译:我们研究了早期植入后小鼠发育过程中编码胸腺素β4(T beta 4),一种小的酸性肌动蛋白-分离肽的mRNA的时空分布。对总胚RNA的分析表明,在胃泌乳后,Tβ4基因被强烈激活,并与神经发生同时发生。原位杂交表明,T beta 4 mRNA在中枢神经系统和周围神经节中强烈表达,与神经元分化的梯度平行。在脑室内巨噬细胞和血管中也观察到强烈的信号。讨论了T beta 4在哺乳动物神经胚发生中的作用。

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