Systematic review of submental artery island flap versus free flap in head and neck reconstruction

摘要

Purpose: The aim of this systematic review is to compare the perioperative characteristics and outcomes of submental artery island flap (SAIF) to free tissue transfer (FTT) in head and neck reconstruction. Materials and methods: Screening and data extraction were done with Pubmed, Embase, and Web of Science databases by two independent authors to identify randomized and observational studies that compared patient outcomes for SAIF vs. FTT for reconstruction head and neck cancer ablative surgery. Data were pooled with random-effects meta-analysis to determine pooled difference in means (DM), absolute risk differences, and 95 confidence intervals (CI). Heterogeneity was assessed with the I-squared statistic. Results: Initial query yielded 997 results, of which 7 studies met inclusion criteria. The pooled sample sizes for the SAIF and FTT cohorts were 155 and 198, respectively. SAIF reduced mean operative time by 193 min (95 CI -160 to -227), reduced hospital stay by 2.1 days (95 CI -0.9 to -3.4), and had a smaller flap area of 22.5cm2 (95 CI 6.5 to 38.4). SAIF had a 5 higher incidence of partial flap necrosis than FTT (95 CI, 1 to 10), but all other perioperative complications, including recurrence rate in malignant cases, were statistically comparable. Conclusions: The SAIF requires less operative time, hospital stay, and has comparable perioperative outcomes to FTT, but the area of flap harvest is significantly smaller. The findings of this study add to the growing body of evidence demonstrating the safety and reliability of SAIF in head and neck reconstruction.