Free-Radical Lipid Oxidation in the Rat Hypothalamus in Stress Following Cortisol Administration

摘要

Free-radical lipid oxidation processes were studied in the hypothalamus in rats after administration of cortisol. Three doses of cortisol (25 mg/kg/day) decreased the level of lipid oxidation end products – Schiff bases – by a mean factor of 1.4. Application of stress to control animals increased the level of Schiff bases. In animals given cortisol, free-radical lipid oxidation process were significantly more marked than those in the stressed control group: along with an increase in end products (Schiff bases), there was a decrease in the intermediate products of free-radical oxidation. Thus, administration of cortisol can lead to longlasting changes in free-radical lipid oxidation in the hypothalamus of both control and stressed rats.