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首页> 外文期刊>Neuroscience and behavioral physiology >Blockade of corticoliberin receptors prevents the development of post-stress psychopathology in rats with an active strategy of adaptive behavior
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Blockade of corticoliberin receptors prevents the development of post-stress psychopathology in rats with an active strategy of adaptive behavior

机译:皮质糖皮质激素受体的阻断通过积极的适应行为策略阻止了大鼠应激后心理病理的发展

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摘要

Active and passive Wistar rats were subjected to single water immersions, after which they showed signs of post-stress depression. Administration on this background of the peptide CRH-R1 receptor blocker astressin prevented the development of behavioral deficit in active individuals but had no effect on the behavior of passive rats. These results lead to the conclusion that corticoliberin receptor blockers are effective in the treatment of post-stress depression only for individuals with an initially active behavioral strategy.
机译:主动和被动Wistar大鼠都要进行一次水浸,然后显示出压力后抑郁的迹象。在这种背景下施用肽CRH-R1受体阻滞剂阿斯汀可预防主动个体的行为缺陷的发展,但对被动大鼠的行为没有影响。这些结果得出的结论是,仅针对具有初始积极行为策略的患者,皮质类固醇激素受体阻滞剂可有效治疗压力后抑郁。

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