Efficacy of Adepress (paroxetine) in generalized anxiety disorder

摘要

The aim of the present work was to study the efficacy of Adepress (paroxetine) in different clinical variants of generalized anxiety disorder (GAD) with consideration of comorbid states. Adepress was used as monotherapy for 42 days. Patients' status was evaluated using the Hamilton anxiety scale (HAM-A) before treatment and then at weekly follow-ups. A total of 49 patients were included in the study and 45 completed it; mean age was 36.2±8.2 years. Patients were divided into two groups depending on whether their condition was dominated by somatic (24 cases) or cognitive (21) anxiety. Adepress was effective in both isolated GAD and GAD complicated by comorbid mental pathology. When somatic anxiety dominated the structure of GAD, treatment effects with Adepress started at treatment weeks 3-4. GAD with a predominance of cognitive anxiety regressed at 3-6 weeks of treatment.