Free-Radical Lipid Oxidation in the Brains of Active andPassive Rats during the Development of Post-Stress Depression

摘要

Free-radical lipid oxidation was studied in the cerebral cortex, striatum, hippocampus, and hypothalamusof KHA and KLA rats (Koltushi High and Low Avoidance) during the development of post-stress depres-sion. After unavoidable emotional-pain exposure, changes in the free-radical oxidation of lipids were pha-sic in nature and had a clear structural specificity in the early phases. During the maximum developmentof depression, the most marked impairments to lipid peroxidation were seen in KHA rats in the striatumand hippocampus, while the greatest changes in KLA rats were seen in the striatum and hypothalamus.These data support the important role of the initial behavioral strategy in the pathogenetic mechanismsforming post-stress psychopathology.