Hormonal Markers of Cognitive Impairments in Patients with Primary Cerebral Stroke

摘要

Serum hormone levels - thyroid-stimulating hormone, thyroxine, dehydroepiandrosterone (DHEA), DHEA sulfate, and prolactin - were studied in patients during the acute period of cerebral ischemic stroke with cognitive impairments of different severities on days 1,7, and 21 of illness. An association was found between the concentrations of these hormones and the severity of cognitive impairments and this supports the view that they have roles in supporting cognitive functions and impairments to cognitive functions during the acute period of stroke. Deficiencies in the study hormones were most marked in the group with severe cognitive impairment. Analysis of the hormonal component of the regulation of the cognitive domain identified the leading biochemical pattern - a decrease in the concentration of the neurosteroid DHEA throughout the acute period of stroke with significant cognitive deficit.