Convulsive Activity in the Electroencephalogram in Rats Sensitive and Tolerant to Pentylenetetrazol Kindling

摘要

Studies on rats divided into two groups with different sensitivities on the basis of manifest convulsiveactivity in response to pentylenetetrazol kindling showed that both "tolerant" and "sensitive" rats showedconvulsive discharges on EEG traces. However, as compared with values in "tolerant" rats, the number ofconvulsive discharges in "sensitive" rats was 60% greater, convulsive discharges occurred 45 sec later, andhad a duration in the first 45 post-injection minutes which was 70% longer. There was no differencebetween the mean durations of convulsive discharges in the two groups. The EEG frequency power peakin "tolerant" rats was more marked than that in "sensitive" animals, and was located at 7.2 Hz. These dataled to the conclusion that pentylenetetrazol kindling induces epileptic activity on the EEG in rats inde-pendently of whether or not the animals showed behavioral seizures, though there were significant differ-ences in measures of this activity in "sensitive" and "tolerant" rats.