Activity in the Hypothalamo-Hypophyseal-Adrenocortical System on Experimental Induction of Chronic Fatigue Syndrome

摘要

Changes in the activity of the hypothalamo-hypophyseal-adrenocortical system (HHACS) were studied inan experimental model of chronic fatigue syndrome induced by i.p. administration of synthetic double-stranded RNA (polyriboinosinic:polyribocytidylic acid, Poly I:C) at a dose of 3 mg/kg. Functionalchanges in the different components of the HHACS were detected using standard tests with i.p. ACTH orhydrocortisone on the background of cold stress and injections of Poly I:C. Single doses of Poly I:C werefollowed by the development of impairments to HHACS function, with decreases in the ACTH sensitivityof adrenal cells and suppression of the negative feedback mechanism, resulting in significant decreases incorticosterone concentrations in standard tests with administration of ACTH and hydrocortisone.