Changes in psychoemotional status in conditions of suppressed immunogenesis in mice and rats. Correction of impairments with GABA-positive agents

摘要

Behavioral and immune reactions were studied in rats and mice with cyclophosphamide immunosuppression. GABAergic agents were found to have psychoimmunostimulating effects. Indexes of delayed-type hypersensitivity and passive hemagglutination antibody titers were measured. The psychophysiological state of the animals was studied using a new model - the Suok test. Administration of phenibut (25 mg/kg) and baclofen (10 mg/kg) restored immune system activity and normalized behavioral reactions, i.e., horizontal and purposive investigative activity, decreased grooming and the duration of freezing, and increased the number of transfers through the central zone and other measures.