Effects of Helium-Neon Laser Irradiation and Local Anesthetics on Potassium Channels in Pond Snail Neurons

摘要

Intracellular dialysis and membrane voltage clamping were used to show that He-Ne laser irradiation of a pond snail neuron at a dose of 0.7·10·4 J (power density 1.5·102 W/m2) increases the amplitude of the potential-dependent slow potassium current, while a dose of 0.7·10·3 J decreases this current. Bupivacaine suppresses the potassium current. Combined application of laser irradiation at a dose of 0.7·10·3 J increased the blocking effect of 10 μM bupivacaine on the slow potassium current, while an irradiation dose of 0.7·10·4 J weakened the effect of bupivacaine.