Irving Page Lecture: 5-HT(2A) serotonin receptor biology: interacting proteins, kinases and paradoxical regulation.

Roth BL

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Irving Page Lecture: 5-HT(2A) serotonin receptor biology: interacting proteins, kinases and paradoxical regulation.

机译：Irving Page讲座：5-HT（2A）血清素受体生物学：相互作用的蛋白质，激酶和矛盾调节。

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5-hydroxytryptamine(2A) (5-HT(2A)) serotonin receptors are important pharmacological targets for a large number of central nervous system and peripheral serotonergic medications. In this review article I summarize work mainly from my lab regarding serotonin receptor anatomy, pharmacology, signaling and regulation. I highlight the role of serotonin receptor interacting proteins and the emerging paradigm of G-protein coupled receptor functional selectivity.

机译：5-羟色胺（2A）（5-HT（2A））5-羟色胺受体是大量中枢神经系统和外周血清素药物的重要药理靶标。在这篇综述文章中，我总结了主要来自我实验室的有关血清素受体解剖学，药理学，信号传导和调节的工作。我着重介绍了血清素受体相互作用蛋白的作用以及G蛋白偶联受体功能选择性的新兴范例。

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《Neuropharmacology》 |2011年第3期|共7页
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Roth BL;
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正文语种 eng
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1. Irving Page Lecture: 5-HT(2A) serotonin receptor biology: interacting proteins, kinases and paradoxical regulation. [J] . Roth BL Neuropharmacology . 2011,第3期

机译：Irving Page讲座：5-HT（2A）血清素受体生物学：相互作用的蛋白质，激酶和矛盾调节。
2. Effect of chronic activation of 5-HT 3 receptors on 5-HT 3, 5-HT 1A and 5-HT 2A receptors functional activity and expression of key genes of the brain serotonin system [J] . KondaurovaE.M., NaumenkoV.S., PopovaN.K. Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2012,第1期

机译：5-HT 3受体的慢性激活对5-HT 3、5-HT 1A和5-HT 2A受体功能活性和脑5-羟色胺系统关键基因表达的影响
3. Effect of chronic activation of 5-HT 3 receptors on 5-HT 3, 5-HT 1A and 5-HT 2A receptors functional activity and expression of key genes of the brain serotonin system [J] . KondaurovaE.M., NaumenkoV.S., PopovaN.K. Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2012,第1期

机译：5-HT 3受体的慢性激活对5-HT 3、5-HT 1A和5-HT 2A受体功能活性和脑5-羟色胺系统关键基因表达的影响
4. MICROGRAVITY AND SIGNALING MOLECULES IN RAT OSTEOBLASTS: DOWNSTREAM OF RECEPTOR TYROSINE KINASE, G-PROTEIN-COUPLED RECEPTOR, AND SMALL GTP-BINDING PROTEINS [C] . Yasuhiro Kumei, Hitoyata Shimokawa, Sadao Morita, European Symposium on Life Sciences in Space . 2005

机译：大鼠成骨细胞中的微匍匐和信号分子：受体酪氨酸激酶，G蛋白偶联受体和小GTP结合蛋白的下游
5. 5-HT(2A) serotonin receptors: Modulation of trafficking and signaling by scaffold proteins. [D] . Bhatnagar, Anushree. 2005

机译：5-HT（2A）血清素受体：通过支架蛋白调节运输和信号传导。
6. 5-HT2A SEROTONIN RECEPTOR BIOLOGY: Interacting proteins kinases and paradoxical regulation [O] . Bryan L Roth -1

机译：5-HT2A血清素受体生物学：相互作用蛋白质激酶和矛盾调节
7. Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT_2Aor 5-HT_2Creceptors [O] . Seitz Patricia K, Bremer Nicole M, McGinnis Andrew G, 2012

机译：在稳定表达5-羟色胺（5-HT）5-HT _{2a 或5-HT _{2C 受体的CHO细胞中平行测量细胞内钙和细胞外调节激酶活化的数量变化}}

Irving Page Lecture: 5-HT(2A) serotonin receptor biology: interacting proteins, kinases and paradoxical regulation.

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