A Synthetic Approach to Perhydro-3-isoquinolinones Bearing an Angular Methyl Group via Organocuprate Addition

摘要

The addition of organocuprates to the activated C-C double bond in 2H-3, 3a, 4, 5, 6, 7-hexahydro-2-indenone followed by trapping of the anionic intermediate with MeI as electrophile is reported. Structural assignment of the resulting product was carried out via its oxime using X-ray diffraction. A subsequent Beckmann rearrangement gave the desired title compound.