4-Aminobicyclo[2.2.2]octanone Derivatives with Antiprotozoal Activities

摘要

4-Aminobicyclo[2.2.2]octanones which were prepared in one-pot-reactions from benzylidene acetone and dialkylammonium rhodanides were erduced stereoselectively to their corresponding alcohols The activities fo the bicylic compounds againat causative organisms of tropical deseased were examined The 4-aminobiclo [2.2.2]octan-2-ols were in general mor eactive against Trypanosoma b.rhodesiense and Plasmodium falciparum than the corresponding keto compounds.