An Efficient and Practical Method for the Synthesis of 1-(2,6-Difluorobenzoyl)-3-(2-alkyl-3-oxopyridazin-4-yl)ureas as Potential Chitin Synthesis Inhibitors

摘要

A mild and efficient method for the synthesis of 4-amino-3(2H)-pyridazinones from their corresponding 4,5-dichloropyridazinones under microwave-assisted conditions is described.A series of novel chitin synthesis inhibitors,benzoylphenylureas containing the 3(2H)-pyridazinone,were synthesized.The biological activity of these target compounds was evaluated.