Synthesis of Side Chain Substituted 3-Butylisocoumarins and Absolute Configurations of Natural Isocoumarins from Artemisia dracunculus

摘要

A series of 3-hydroxy-and 3-bromobutyl-substituted isocoumarins was synthesized.The absolute configurations of three isocoumarin derivatives from Artemisia dracunculus,namely(-)-epxyartemidin,(-)-2'-methoxydihydroartemidin,and(+)-3'-hydroxyartemidin were determinedby chemical means via derivatization,kinetic racemate resolution(Horeau method),and comparison of the circular dichroism(CD)spectra.