Electrochemical and spectral characterization of the host-guest inclusion complex of the antiparasitic drug nitazoxanide with P-cyclodextrin

摘要

The formation of a host-guest inclusion complex of the antiparasitic drug nitazoxanide (NTZ) with β-cyclodextrin (β-CD) in aqueous solution has been characterized by electrochemical methods, cyclic and differential pulse voltammetry, and UV-Vis absorption spectroscopy. The nature of the host-guest inclusion complex between NTZ and β-CD has been elucidated. The experimental results confirmed the existence of 1:1 inclusion complex of NTZ with β-CD. The binding constants describing the extent of formation of the complexes have been determined, using Benesi-Hildebrand plots, using voltammetry and UV-Vis spectroscopy. NTZ exhibits an affinity for β-CD. A special configuration of the complex has been proposed.