Synthesis, characterization, and biological evaluation of Schiff bases containing indole moiety and their derivatives

摘要

In the present study series of new Schiff bases containing indole moiety such as N'-[(5-substituted-2-phenyl-1H-indol-3-yl)methylene]-2-oxo-2H-chromene-3-carbohydrazide and their cyclocondensation products N-[2-(5-substituted-2-phenyl-1H-indol-3-yl)-4-oxothiazolidin-3-yl]-2-oxo-2H-chromene-3-carboxamides, 3-[4-acetyl-5-(5-substituted-2-phenyl-1H-indol-3-yl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2H-chromen-2-ones, 3-[5-(5-substituted-2-phenyl-1H-indol-3-yl)-1,3,4-oxadiazol-2-yl]-2H-chromen-2-ones, and 3-chloro-4-(5-substituted-2-phenyl-1H-indol-3-yl)-1-(2-oxo-2H-chromene-3-carbonyl)azetidin-2-ones were prepared. The structures of the newly synthesized compounds have been confirmed on the basis of their elemental analyses, IR, H-1 and C-13 NMR, and mass spectral studies. These compounds were screened for their antioxidant and antimicrobial activities. Some of the compounds exhibited good antioxidant and antimicrobial activity.