Phosphine-free copper-mediated Sonogashira coupling reaction

摘要

A new, efficient, and inexpensive system has been developed to catalyze Sonogashira cross-coupling reactions between aryl iodides and terminal alkynes. We have employed CuO as well as a novel polymer-supported Cu-N-heterocyclic carbene complex, synthesized using ethanolamine as a ligand, base, and solvent. The reaction conditions were mild and products were obtained in good to excellent yields. The developed catalytic system can be recovered and reused with minimal loss of activity.