Facile one-pot synthesis of polysubstituted quinollnes under solvent-free conditions using sulfamic acid as a reusable catalyst

摘要

A facile one-pot synthesis of polysubstituted quinoline derivatives has been demonstrated by using sulfamic acid as a reusable catalyst under solvent-free conditions. The synthetic method provides the basis and advantages of a simple experimental procedure and easy recovery and reuse of catalyst, which makes it a highly practical and environmentally benign pathway for the synthesis of polysubstituted quinolines. Interestingly, this one-pot synthesis could produce the products regioselec-tively in the presence of dis-symmetrical arylamines.