DNA combining and photocleaving properties of photosensitizer-encapsulated silica nanoparticles

摘要

Based on theoretical predictions, water-soluble silica nanoparticle encapsulated hypocrellin A (HA) was prepared, and its photosensitization activity was evaluated. The encapsulated HA showed not only very good water solubility, but also much stronger singlet oxygen generation ability than free HA. Investigations on binding interactions with DNA showed promising results as well. These findings suggest that HA carrier can exert photo-dynamic action via photosensitization.