A novel one-pot and rapid synthesis of polyfunctionalized benzoapyrimido5',4':5,6 pyrido2,3-cphenazine derivatives under microwave irradiation

摘要

A one-pot, environmentally friendly, and efficient protocol for the synthesis of novel polyfunctionalized benzo$a$pyrimido5',4':5,6pyrido2,3-$c$phenazine derivatives has been reported by a one-pot, four-component sequential reaction between 2-hydroxynaphthalene-1,4-dione, benzene-1,2-diamines, benzaldehydes, and 6-amino-1,3-dimethyluracil in the presence of $p$-TSA as a nontoxic, inexpensive, ecofriendly, and efficacious solid acid catalyst. Two C-C bonds, two C=N bonds, and one C-N bond, as well as two new rings, were formed in this reaction. Through this procedure, compounds with substantial biological and pharmaceutical properties are generated in a single operation. Factors such as high yields, less reaction time, operational simplicity, and lack of any dangerous reagents/solvents have made this process a green one.