A Novel Application of F-18Fluorothymidine-PET (F-18FLT-PET) in Clinical Practice to Quantify Regional Bone Marrow Function in a Patient With Treatment-Induced Cytopenias and to Guide 'Marrow-Sparing' Radiotherapy

摘要

F-18-Fluorothymidine-positron emission tomography with CT fusion (F-18FLT-PET/CT) offers a unique and non-invasive method for three-dimensional localization and quantification of functional bone marrow. F-18FLT-PET/CT has potential application in radiotherapy planning when risk of marrow toxicity is a significant clinical concern. In this patient with chemo-refractory, transformed lymphoma and treatment-induced cytopenias, F-18FLT-PET/CT was a novel and useful adjunct to (1) image the distribution of functional bone marrow reserve, (2) guide "marrow-sparing" radiotherapy planning, and (3) quantify the effects of radiotherapy-induced bone marrow suppression both in-field and out-of-field.