Ictal focal hyperperfusion demonstrated by arterial spin-labeling perfusion MRI in partial epilepsy status

摘要

Pulsed arterial spin-labeling (PASL) perfusion magnetic resonance imaging (MRI) is a noninvasive method of measuring regional cerebral blood flow (rCBF) without contrast medium and has been routinely applied in cerebrovascular diseases as a cerebral perfusion measurement [1]. In partial epilepsy, ictal cortical hyperperfusion is believed to be a useful marker for identifying epileptogenic zone, and single-photon emission computed tomography (SPECT) is commonly used for evaluating differences between interictal and ictal cerebral perfusions. Few reports have described hemo-dynamic changes detected by PASL in interictal [2-4] and peri-ictal states [5,6]. Recently, we had a rare opportunity to conduct PASL imaging and also diffusion-weighted imaging (DWI) of a patient both in partial epilepsy status (PES) and during the interictal state.