The global epidemiology of hereditary ataxia and spastic paraplegia: a systematic review of prevalence studies.

摘要

Highly variable prevalence values for HCA and HSP are reported across the world. This variation reflects the different genetic make-up of the populations, but also methodological heterogeneity. Large areas of the world remain without prevalence studies. From the available data, we estimated that around 1:10,000 people are affected by HCA or HSP. In spite of advances in genetic research, most families in population-based series remain without identified genetic mutation after extensive testing. ? 2014 S. Karger AG, Basel.